Sequential Production of Birbeck Granules Through Adsorptive Pinocytosis
نویسندگان
چکیده
منابع مشابه
Non-specific adsorptive pinocytosis.
Unlike phagocytosis, which is typically a substrate-induced phenomenon, pinocytosis appears to be a constitutive activity in most animal cell types (see Pratten et al., 1980; Steinman et al., 1983). Pinocytic vesicles are constantly being formed from invaginations of the plasma membrane, irrespective of the availability of substrates; hence the analogies of a paternoster-style elevator (Lloyd, ...
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We have previously shown that poly a$-( N-2-hydroxyethyl)-D,L-aspartamide is captured by rat visceral yolk sacs cultured in vitro by pinocytosis (Duncan et al., 1982) and also that substitution of the parent polymer with tyramine residues (19.2molX) caused a marked increase in its rate of capture. In this study we have investigated this phenomenon further by synthesizing a series of polyasparta...
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We have examined, by analyzing thin (15-20 nm) serial sections, whether coated pits involved in adsorptive pinocytosis in cultured fibroblasts give rise to free coated vesicles or represent permanently surface-associated structures from the neck of which uncoated receptosomes pinch off and carry ligand into the cell. Human skin fibroblasts and mouse L-929 fibroblasts were incubated with cationi...
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An increase in the concentration of serum resulted in a very marked increase in the rate of fluid-phase pinocytosis in rat peritoneal macrophages, as measured by the uptake of 1251-1abelled polyvinylpyrrolidone. In contrast , the rate of uptake of colloidal [198Au]gold, an a d s o r p t i v e s u b s t r a t e , d e c r e a s e d when t h e s e r u m concentration was increased. This lessened u...
متن کاملDisruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function.
Langerin is a C-type lectin expressed by a subset of dendritic leukocytes, the Langerhans cells (LC). Langerin is a cell surface receptor that induces the formation of an LC-specific organelle, the Birbeck granule (BG). We generated a langerin(-/-) mouse on a C57BL/6 background which did not display any macroscopic aberrant development. In the absence of langerin, LC were detected in normal num...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1984
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12259049